Whole-Genome Sequencing of Childhood Cancer Survivors Treated with Cranial Radiation Therapy Identifies 5p15.33 Locus for Stroke: A Report from the St. Jude Lifetime Cohort Study.
Yadav SapkotaYin Ting CheungWon Jong MoonKyla C SheltonCarmen L WilsonZhaoming WangDaniel A MulrooneyJinghui ZhangGregory T ArmstrongMelissa M HudsonLeslie L RobisonKevin R KrullYutaka YasuiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
A novel locus 5p15.33 is associated with stroke risk among childhood cancer survivors, with a possible CRT dose-specific effect. The locus is of potential clinical utility in characterizing individuals who may benefit from surveillance and intervention strategies.