Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes.

Maria A AhonenMarcus HöringVan Dien NguyenSami QadriJuuso H TaskinenMeghana NagarajMartin WabitschPamela Fischer-PosovszkyYou ZhouGerhard LiebischP A Nidhina HaridasHannele Yki-JärvinenVesa M Olkkonen

Published in: Molecular medicine (Cambridge, Mass.) (2022)

THRSP is regulated by insulin both in vivo in human adipose tissue and in vitro in adipocytes, and its expression is downregulated by insulin resistance. As THRSP silencing decreases mitochondrial respiration and fatty acid oxidation, its downregulation in human adipose tissue could contribute to mitochondrial dysfunction. Furthermore, disturbed sphingolipid metabolism could add to metabolic dysfunction in obese adipose tissue.

Keyphrases

adipose tissue
insulin resistance
endothelial cells
type diabetes
high fat diet
induced pluripotent stem cells
oxidative stress
fatty acid
metabolic syndrome
cell proliferation
skeletal muscle
glycemic control
binding protein
obese patients