Marine debris substantially threatens the world's marine ecosystems, national economies, and human well-being, particularly those living in the coastal areas. Among the types of marine debris, abandoned, lost, and discarded fishing gears (ALDFGs) are the most challenging, contributing substantially to marine pollution. The Sulu-Sulawesi Seas, a region rich in biodiversity but heavily impacted by fishing activities and ALDFGs, is the focus of this study. In proposing trilateral cooperation between the Philippines, Indonesia, and Malaysia, this paper suggests an eco-regional approach to mitigate its effects. An eco-regional approach looks to balancing ecology and societal needs, integrating environmental conservation and biodiversity with human requirements. The paper explores the effects of ALDFGs on the environment and society, reviews existing national and international laws, and advocates for a trilateral cooperation through eco-regional approach as an effective mitigation method.