Alkoxy chain length governs the potency of 2-benzylbenzimidazole 'nitazene' opioids associated with human overdose.

Grant C GlatfelterMarthe M VandeputteLi ChenDonna WaltherMeng-Hua M TsaiLei ShiChristophe P StoveMichael H Baumann

Published in: Psychopharmacology (2023)

Overall, our data show that certain nitazene NSOs are more potent than fentanyl as MOR agonists in mice, highlighting concerns regarding the high potential for overdose in humans who are exposed to these compounds.

Keyphrases

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