Impact of spatial clustering of cytotoxic and tumor infiltrating lymphocytes on overall survival in women with high grade serous ovarian cancer.
Alex C SoupirMary K TownsendCassandra A HathawayJonathan V NguyenCarlos Moran SeguraDaryoush Saeed-VafaOscar E OspinaLauren C PeresJose R Conejo-GarciaKathryn L TerryShelley S TworogerBrooke L FridleyPublished in: medRxiv : the preprint server for health sciences (2024)
High abundance of TILs and CTLs that are spatially distributed across the tumor was associated with better survival, replicating our work in non-Hispanic Black women, and supporting that the spatial architecture of the tumor microenvironment is an important predictor of survival in HGSOC.