Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response.
Yangyang QiYuan ChangZewei WangLingli ChenYunyi KongPeipei ZhangZheng LiuQuan ZhouYifan ChenJiajun WangQi BaiYu XiaLi LiuYu ZhuLe XuBo DaiJianming GuoYiwei WangJiejie XuWeijuan ZhangPublished in: Cancer immunology, immunotherapy : CII (2019)
Gal-9+TAMs predicted OS and RFS and response to ACT in MIBC patients. High Gal-9+TAMs were associated with a pro-tumor immune contexture concomitant with T cell exhaustion.