Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation.

Khalid Mohamed El-Say Osama Abdelhakim Aly Ahmed Amir I Mohamed Martin K SafoAbdelsattar M Omar

Published in: International journal of nanomedicine (2019)

The clinical findings suggest 194% enhancement of relative bioavailability of the optimized DPX-loaded NPs, potentially leading to a decrease in therapeutic dose and associated side effects in the treatment of PE.

Keyphrases

drug delivery
cancer therapy
wound healing
replacement therapy