Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation.
Khalid Mohamed El-SayOsama Abdelhakim Aly AhmedAmir I MohamedMartin K SafoAbdelsattar M OmarPublished in: International journal of nanomedicine (2019)
The clinical findings suggest 194% enhancement of relative bioavailability of the optimized DPX-loaded NPs, potentially leading to a decrease in therapeutic dose and associated side effects in the treatment of PE.