A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS.

Simon GollinsNicholas WestDavid Sebag-MontefioreShabbir SusnerwalaStephen FalkNick BrownMark SaundersPhilip QuirkeRuby RayPhilip ParsonsGareth GriffithsTim MaughanRichard AdamsChristopher N Hurt

Published in: British journal of cancer (2018)

The regimen was well tolerated with effective downstaging and encouraging PFS. mrTRG response to NAC may be a new prognostic factor for long-term PFS, but needs validation in larger studies.

Keyphrases

locally advanced
phase ii study
prognostic factors
rectal cancer
transcription factor
squamous cell carcinoma
radiation therapy
case control
randomized controlled trial
clinical trial
early stage
radiation induced
study protocol
open label
double blind