Effectiveness of nirmatrelvir-ritonavir for the treatment of patients with mild to moderate COVID-19 and at high risk of hospitalization: Systematic review and meta-analyses of observational studies.
Kathiaja Miranda SouzaGabriela CarrascoRobin Rojas-CortésMariana Michel BarbosaEduardo Henrique Ferreira BambirraJosé Luis CastroJuliana Alvares-TeodoroPublished in: PloS one (2023)
The results suggest that nirmatrelvir-ritonavir could be effective in reducing mortality and hospitalization. The results were valid in vaccinated or unvaccinated high-risk individuals with COVID-19. Data from ongoing and future trials may further advance our understanding of the effectiveness and safety of nirmatrelvir-ritonavir and help improve treatment guidelines for COVID-19.