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Clopidogrel vs. prasugrel vs. ticagrelor in patients with acute myocardial infarction complicated by cardiogenic shock: a pooled IABP-SHOCK II and CULPRIT-SHOCK trial sub-analysis.

Martin OrbanJan KleebergerTaoufik OuarrakAnne FreundHans-Josef FeistritzerGeorg FuernauTobias GeislerKurt HuberDariusz DudekMarko NocGilles MontalescotAlexander NeumerPaul HallerPeter ClemmensenUwe ZeymerSteffen DeschSteffen MassbergSteffen SchneiderHolger ThieleJörg Hausleiter
Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)
This pooled sub-analysis is the largest analysis on safety and efficacy of three oral ADP-receptor antagonists and shows that acute therapy with either clopidogrel, prasugrel or ticagrelor is no independent predictor of 1-year mortality. Treatment with ticagrelor seems independently associated with less in-hospital moderate and severe bleeding events compared to clopidogrel. This finding might be due to selection bias and should be interpreted with caution.
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