[On the role of endogenous retroviruses in tumor growth biology].
G D SidelnikovA R ValikhovPublished in: Voprosy onkologii (2019)
Retrotransposons are the mobile part of the genetic material in mammals. Such a close proximity is a unique in its kind example of the genetic symbiosis. As a result of long-term co-evolution retroviruses purchased the actual immortality and protection from adverse factors, providing instead the recombinant opportunities of its genetic apparatus for the implementation of the evolutionary, adaptive and biological processes that are vital to the host organism. The consequence of the violation of the established biological balance is the pathological activity of retrotransposons that can affect the expression of any gene. This review examines the point of view on the key role of retrotrasposons in the biology of tumor development as a result of aggressive parasitism and speculates about the causes of the violations of adequate immune response in the process of tumor growth.