The WUR0000125 PRRS resilience SNP had no apparent effect on pigs' infectivity and susceptibility in a novel transmission trial.

Margo Chase-ToppingGraham PlastowJack DekkersYanhua LiYing FangVolker GerdtsJill Van KesselJohn HardingTanja OpriessnigAndrea Doeschl-Wilson

Published in: Genetics, selection, evolution : GSE (2023)

The novel design demonstrated that it is possible to estimate genotype effects on Shedder pig infectivity and Contact pig susceptibility that are not confounded by family effects. The study, however, provided no supportive evidence that genetic selection on WUR genotype would affect PRRSV-2 transmission. The results of this study need to be independently validated in a larger trial using different PRRSV strains before dismissing the effects of the WUR marker or the previously detected GBP5 gene on PRRSV transmission.

Keyphrases

genome wide
clinical trial
study protocol
escherichia coli
phase iii
copy number
randomized controlled trial
magnetic resonance imaging
climate change
computed tomography