Crosstalk Between CD4+ T Cells and Airway Smooth Muscle in Pediatric Obesity-related Asthma.
Changsuek YonDavid A ThompsonJoseph A JudeReynold A PanettieriDeepa RastogiPublished in: American journal of respiratory and critical care medicine (2022)
Obese asthma TH cells have uninhibited chemotaxis and are more adherent to obese ASM, which is associated with upregulation of genes and proteins associated with smooth muscle proliferation and reciprocal non-atopic TH cell activation.
Keyphrases
- smooth muscle
- weight loss
- metabolic syndrome
- chronic obstructive pulmonary disease
- induced apoptosis
- lung function
- type diabetes
- adipose tissue
- signaling pathway
- bariatric surgery
- insulin resistance
- allergic rhinitis
- cell cycle arrest
- obese patients
- single cell
- cell therapy
- cell proliferation
- genome wide
- poor prognosis
- weight gain
- endoplasmic reticulum stress
- cystic fibrosis
- gene expression
- high fat diet induced
- transcription factor
- skeletal muscle
- long non coding rna
- body mass index
- genome wide identification
- physical activity
- mesenchymal stem cells