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Major Achievements in the Design of Quadruplex-Interactive Small Molecules.

Eduarda MendesIsraa M AljnadiBárbara BahlsBruno Lourenço VictorAlexandra Paulo
Published in: Pharmaceuticals (Basel, Switzerland) (2022)
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic acids have great potential as selective drugs or as tools in drug target discovery programs, or even in the development of nanodevices for medical diagnosis. Hundreds of quadruplex-interactive small molecules have been reported, and the challenges in their design vary with the intended application. Herein, we survey the major achievements on the therapeutic potential of such quadruplex ligands, their mode of binding, effects upon interaction with quadruplexes, and consider the opportunities and challenges for their exploitation in drug discovery.
Keyphrases
  • drug discovery
  • healthcare
  • public health
  • small molecule
  • cross sectional
  • high throughput
  • emergency department
  • risk assessment
  • binding protein
  • human health
  • climate change
  • electronic health record