11-Oxygenated androgens are not secreted by the human ovary: in-vivo data from four different cases of hyperandrogenism.

Matthias K AuerJames M HawleyChristian LottspeichMartin BidlingmaierAndrea SapplHanna F NowotnyLea TschaidseMarcus TreitlMartin ReinckeBrian G KeevilNicole Reisch

Published in: European journal of endocrinology (2022)

This study confirms that 11β-hydroxyandrostenedione (11-OHA4) and 11-ketotestosterone (11-KT) are not biosynthesized by the human ovary. We propose that the testosterone/11-KT ratio as well as 11-OHA4 could help to identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
type diabetes
electronic health record
metabolic syndrome
adipose tissue
polycystic ovary syndrome
machine learning