Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.
Takahiro NiikuraTakahiro OdaNaoe JimboMasato KomatsuKeisuke OeTomoaki FukuiTomoyuki MatsumotoShinya HayashiTakehiko MatsushitaTomoo ItohRyosuke KurodaPublished in: Journal of orthopaedic surgery and research (2022)
This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.
Keyphrases
- bone mineral density
- bone regeneration
- end stage renal disease
- newly diagnosed
- soft tissue
- endothelial cells
- bone loss
- ejection fraction
- chronic kidney disease
- poor prognosis
- high glucose
- postmenopausal women
- mesenchymal stem cells
- peritoneal dialysis
- diabetic rats
- quality improvement
- body composition
- single cell
- oxidative stress
- bone marrow
- drug induced
- patient reported outcomes