BMP7-Loaded Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorate Liver Fibrosis by Targeting Activated Hepatic Stellate Cells.
Dan ZhuZongbin SunJiayun WeiYulin ZhangWenjing AnYan LinXun LiPublished in: International journal of nanomedicine (2024)
These engineered BMP7-loaded hucMSC-sEVs offer a novel and promising strategy for the clinical treatment of liver fibrosis.
Keyphrases
- liver fibrosis
- mesenchymal stem cells
- umbilical cord
- drug delivery
- induced apoptosis
- bone marrow
- endothelial cells
- cancer therapy
- cell therapy
- cell cycle arrest
- wound healing
- induced pluripotent stem cells
- oxidative stress
- signaling pathway
- cell death
- pluripotent stem cells
- stem cells
- combination therapy
- endoplasmic reticulum stress
- replacement therapy