CViewer: a Java-based statistical framework for integration of shotgun metagenomics with other omics datasets.
Orges KociRichard K RussellM Guftar ShaikhChristine EdwardsKonstantinos GerasimidisUmer Zeeshan IjazPublished in: Microbiome (2024)
CViewer was used to analyse two distinct metagenomic datasets with varying complexities. These include a dietary intervention study to understand Crohn's disease changes during a dietary treatment to include remission, as well as a gut microbiome profile for an obesity dataset comparing subjects who suffer from obesity of different aetiologies and against controls who were lean. Complete analyses of both studies in CViewer then provide very powerful mechanistic insights that corroborate with the published literature and demonstrate its full potential. Video Abstract.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- weight gain
- randomized controlled trial
- rna seq
- systematic review
- single cell
- disease activity
- systemic lupus erythematosus
- bone mineral density
- skeletal muscle
- rheumatoid arthritis
- combination therapy
- antibiotic resistance genes
- physical activity
- anaerobic digestion