piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine.
Ruitong HanLing ZhangWeidong GanKai FuKe JiangJie DingJiang WuXiaodong HanDongmei LiPublished in: The Prostate (2019)
MC-LR caused downregulation of piRNA-DQ722010 and PIWI proteins, while piRNA-DQ722010 downregulation promoted activation of PI3K/AKT signaling pathway inducing prostate hyperplasia by upregulating the expression of Pik3r3. In contrast, piRNA-DQ722010 downregulation may be attributed to PIWI proteins downregulation.
Keyphrases
- signaling pathway
- pi k akt
- cell proliferation
- celiac disease
- prostate cancer
- induced apoptosis
- epithelial mesenchymal transition
- cell cycle arrest
- poor prognosis
- benign prostatic hyperplasia
- nitric oxide
- high fat diet
- magnetic resonance imaging
- adipose tissue
- type diabetes
- cell death
- metabolic syndrome
- physical activity
- oxidative stress
- contrast enhanced
- endoplasmic reticulum stress
- preterm birth
- insulin resistance