Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer.

X Y CuiM TinholtB StavikA E A DahmS KanseY JinS SeidlK K SahlbergN IversenG SkrettingPer Morten Sandset

Published in: Journal of thrombosis and haemostasis : JTH (2016)

This study demonstrates that HIF-1α is involved in the transcriptional regulation of the TFPI gene, and suggests that a hypoxic microenvironment inside a breast tumor may induce a procoagulant state in breast cancer patients.

Keyphrases

poor prognosis
endothelial cells
stem cells
genome wide
gene expression
transcription factor