The lipid droplet in cancer: From being a tumor-supporting hallmark to clinical therapy.
Yingfang CuiShuli ManJiejing TaoYu LiuLong MaLanping GuoLuqi HuangChangxiao LiuWenyuan GaoPublished in: Acta physiologica (Oxford, England) (2024)
As one of the top ten hallmarks of cancer, abnormal lipid metabolism caused by excessive generation of LDs interrelates with other hallmarks. The crosstalk between excessive LDs and intracellular free fatty acids (FFAs) promotes an inflammatory environment that supports tumor growth. Moreover, LDs contribute to cancer metastasis and cell death resistance in vivo. Statins, as HMGCR inhibitors, are promising to be the pioneering commercially available anti-cancer drugs that target LD formation.
Keyphrases
- papillary thyroid
- cell death
- fatty acid
- squamous cell
- cardiovascular disease
- lymph node metastasis
- stem cells
- oxidative stress
- high throughput
- type diabetes
- mesenchymal stem cells
- physical activity
- body mass index
- childhood cancer
- signaling pathway
- cell therapy
- bone marrow
- reactive oxygen species
- smoking cessation
- cell cycle arrest
- replacement therapy