Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo .

Fanghua QiuHuajing LongLu ZhangJieyuan LiuZetian YangXian-Zhang Huang

Published in: Journal of clinical and translational hepatology (2022)

DCD promotes HCC cell migration, invasion, and metastasis through upregulation of noncatalytic region of tyrosine kinase adaptor protein 1 (Nck1), Rac1, Cdc42, WASP, and Arp2/3, which induce actin cytoskeletal remodeling and fibronectin-mediated cell adhesion in HCC cells.

Keyphrases

cell migration
tyrosine kinase
cell adhesion
epidermal growth factor receptor
induced apoptosis
cell cycle arrest
signaling pathway
cell proliferation
poor prognosis
cell cycle
endoplasmic reticulum stress
amino acid
oxidative stress
small molecule
pi k akt