The Expression Levels of IL-4/IL-13/STAT6 Signaling Pathway Genes and SOCS3 Could Help to Differentiate the Histopathological Subtypes of Non-Small Cell Lung Carcinoma.
Dorota Pastuszak-LewandoskaDaria Domańska-SenderowskaAdam AntczakJacek KordiakPaweł GórskiKarolina H CzarneckaMonika Migdalska-SękEwa NawrotJustyna M KiszałkiewiczEwa Brzeziańska-LasotaPublished in: Molecular diagnosis & therapy (2019)
As the number of LCC cases in our study was quite low, the statistically significant results obtained should be confirmed in a larger group of patients, particularly as the relationships identified between increased IL-4, IL-13, and STAT6 mRNA expression and decreased SOCS3 expression suggest that these genes may serve as potential diagnostic markers for differentiating between NSCLC histopathological subtypes.
Keyphrases
- poor prognosis
- signaling pathway
- end stage renal disease
- cell proliferation
- genome wide
- small cell lung cancer
- ejection fraction
- chronic kidney disease
- newly diagnosed
- single cell
- binding protein
- stem cells
- oxidative stress
- gene expression
- computed tomography
- prognostic factors
- bioinformatics analysis
- dna methylation
- genome wide analysis