IFITM3 knockdown reduces the expression of CCND1 and CDK4 and suppresses the growth of oral squamous cell carcinoma cells.

Chai Phei GanKin Kit SamPei San YeeNur Syafinaz ZainalBernard Kok Bang LeeZainal Ariff Abdul RahmanVyomesh PatelAik Choon TanRosnah Binti ZainSok Ching Cheong

Published in: Cellular oncology (Dordrecht) (2019)

From our data we conclude that IFITM3 is overexpressed in OSCC and may regulate the CCND1-CDK4/6-pRB axis to mediate OSCC cell growth.

Keyphrases

cell cycle
poor prognosis
signaling pathway
big data
cell proliferation
binding protein
artificial intelligence