Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway.
Jinze LiQiuke LiQianhui WuNan GaoZhihua WangYang YangAnshan ShanPublished in: Journal of animal science and biotechnology (2023)
EPSs attenuate S.T-induced immune responses by inhibiting the expression of key proteins in the TLR4/NF-κB/MAPK signaling pathway. Moreover, EPSs could promote bacterial aggregation into clusters, which may be a potential strategy for reducing the bacterial invasion of intestinal epithelial cells.
Keyphrases
- signaling pathway
- pi k akt
- immune response
- oxidative stress
- diabetic rats
- toll like receptor
- induced apoptosis
- epithelial mesenchymal transition
- high glucose
- inflammatory response
- poor prognosis
- nuclear factor
- escherichia coli
- lps induced
- dendritic cells
- cell migration
- climate change
- binding protein
- endoplasmic reticulum stress