Expression and role of lumican in acute aortic dissection: A human and mouse study.
Shao-Wei ChenShing-Hsien ChouYing-Chang TungFu-Chih HsiaoChien-Te HoYi-Hsin ChanVictor Chien-Chia WuAn-Hsun ChouMing-En HsuPyng-Jing LinWinston W Y KaoPao-Hsien ChuPublished in: PloS one (2021)
LUM expression was altered in patients with AD display increased s-LUM in blood, and Lum-/- mice exhibited augmented AD pathogenesis. These findings support the notion that LUM is a biomarker signifying the pathogenesis of injured aorta seen in AAD. The presence of LUM is essential for maintenance of connective tissue integrity. Future studies should elucidate the mechanisms underlying LUM association in aortic changes.
Keyphrases
- aortic dissection
- poor prognosis
- binding protein
- long non coding rna
- pulmonary artery
- heart failure
- left ventricular
- pulmonary hypertension
- coronary artery
- induced pluripotent stem cells
- case control
- high fat diet induced
- pulmonary arterial hypertension
- current status
- extracorporeal membrane oxygenation
- mechanical ventilation