Ventilatory and Pharmacotherapeutic Strategies for Management of Adult Patients on Extracorporeal Life Support.
Amy L DzierbaDarryl AbramsJustin MuirDaniel BrodiePublished in: Pharmacotherapy (2019)
Extracorporeal life support (ECLS) can provide mechanical support for patients with severe life-threatening cardiac or respiratory failure. ECLS is a complex therapy that has increased in use over several decades owing to advances in technology. In concert with this growth, there is an increased need to understand the complexity of this technology to augment the effectiveness of ECLS and minimize complications such as ventilator-induced lung injury, bleeding, thrombosis, infections, and inadequate drug dosing. The purpose of this review was to discuss management strategies in adult patients receiving ECLS and provide recommendations on ventilator management, provision of adequate analgesia and sedation, treatment and prevention of infections, and anticoagulation.
Keyphrases
- mechanical ventilation
- respiratory failure
- acute respiratory distress syndrome
- atrial fibrillation
- randomized controlled trial
- extracorporeal membrane oxygenation
- systematic review
- drug induced
- palliative care
- heart failure
- pulmonary embolism
- stem cells
- left ventricular
- early onset
- intensive care unit
- emergency department
- diabetic rats
- mesenchymal stem cells
- young adults
- combination therapy