In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography.

Adrienn KisJudit P SzabóNoémi DénesAdrienn VágnerGábor NagyIldikó GaraiAnikó FeketeDezső SzikraIstván HajduOrsolya MatolayGábor MéhesGábor MezőIstván KertészGyörgy Trencsényi

Published in: BioMed research international (2020)

68Ga-DOTA-nitroimidazole and 68Ga-NOTA-c(NGR) are suitable diagnostic radiotracers for the detection of the temporal changes of hypoxic areas and neoangiogenic molecule (CD13) expression, which vary during tumor growth in a hepatocellular carcinoma model.

Keyphrases

pet ct
positron emission tomography
computed tomography
pet imaging
poor prognosis
high resolution
long non coding rna
fluorescence imaging
quantum dots
sensitive detection