Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.
Ana Carolina Costa MonteiroHeidi FloriMary K DahmerMyung Shin SimMichael W QuasneyMartha A Q CurleyMichael A MatthayAnil Saprunull nullPublished in: Critical care (London, England) (2021)
https://clinicaltrials.gov/ct2/show/NCT00814099 . In healthy lung endothelium, thrombomodulin (TM) recruits thrombin to activate Protein-C (PC/APC), that inhibits plasminogen activator-1 (PAI-1) and thrombosis. In inflamed and damaged endothelium, TM is cleaved into its soluble form (sTM), precluding its usual regulation of thrombosis. In this study, we measured plasma sTM levels in pediatric patients with respiratory failure and found that sTM correlated with mortality and other clinical markers of poor outcomes.
Keyphrases
- respiratory failure
- extracorporeal membrane oxygenation
- mechanical ventilation
- randomized controlled trial
- acute respiratory distress syndrome
- pulmonary embolism
- nitric oxide
- cardiovascular events
- intensive care unit
- risk factors
- study protocol
- computed tomography
- recombinant human
- image quality
- type diabetes
- coronary artery disease
- cardiovascular disease
- clinical trial
- magnetic resonance imaging
- magnetic resonance
- adipose tissue
- amino acid
- insulin resistance
- positron emission tomography
- skeletal muscle
- pet ct