DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring.
Sha LuJiahao WangNisile KakongomaWen HuaJiahui XuYunfei WangShutao HeHongcang GuJiantao ShiWensheng HuPublished in: Clinical epigenetics (2022)
Our research demonstrated the epigenetic and transcriptomic alternations of GDM women and offspring. Our findings emphasized the importance of epigenetic modifications in the communication between pregnant women with GDM and offspring, and provided a reference for the prevention, control, treatment, and intervention of perinatal deleterious events of GDM and neonatal complications.
Keyphrases
- dna methylation
- umbilical cord
- high fat diet
- pregnant women
- gene expression
- genome wide
- mesenchymal stem cells
- end stage renal disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- single cell
- chronic kidney disease
- pregnancy outcomes
- peritoneal dialysis
- polycystic ovary syndrome
- type diabetes
- combination therapy
- smoking cessation