Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.

Rakesh Kumar Nicolas A Nunez Neha S Joshi Boney Joseph Alessandra VerdeAshok SeshadriAlfredo B Cuellar BarbozaLarry J ProkopGustavo C MedeirosBalwinder Singh

Published in: Bipolar disorders (2024)

This systematic review provides preliminary evidence that ketamine may cause changes in several important pathways involved in energy metabolism and inflammation. Larger and more rigorous studies are needed.

Keyphrases

systematic review
pain management
meta analyses
oxidative stress
depressive symptoms
randomized controlled trial
sleep quality