Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes.
Yogita Ghodke-PuranikZhongbo JinKip D ZimmermanHannah C AinsworthWei FanMark A JensenJessica M DorschnerDanielle M VseteckaShreyasee AminAshima MakolFloranne ErnsteThomas OsbornKevin ModerVaidehi ChowdharyCarl D LangefeldTimothy B NiewoldPublished in: Arthritis research & therapy (2021)
We document multiple SLE-risk allele eQTLs in single monocytes which differ greatly between CL and NCL subsets. These data support the importance of the SPP1 and TNFAIP3 risk variants and the IRF1 transcript in SLE patient monocyte function.