Additive value of [ 18 F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome.
Sabrina KatzdoblerAlexander NitschmannHenryk BarthelGerard BischofLeonie BeyerKen MarekMengmeng SongOlivia WagemannCarla PalleisEndy WeidingerAnne NackUrban FietzekCarolin KurzJan HäckertTheresa StapfChristian FerschmannMaximilian ScheifeleFlorian EckenweberGloria BiecheleNicolai FranzmeierAnna DewenterSonja SchöneckerDorothee SaurMatthias L SchroeterJost-Julian RumpfMichael RullmannAndreas SchildanMarianne PattAndrew W StephensThilo van EimerenBernd NeumaierAlexander DrzezgaAdrian DanekJoseph ClassenKatharina BürgerDaniel JanowitzBoris-Stephan RauchmannSophia StöckleinRobert PerneczkyFlorian SchöberlAndreas ZwergalGünter U HöglingerPeter BartensteinVictor VillemagneJohn SeibylOsama SabriJohannes LevinMatthias Brendelnull nullPublished in: European journal of nuclear medicine and molecular imaging (2022)
F]PI-2620 perfusion imaging mirrors known topology of regional hypoperfusion in 4RTs. Single region hypoperfusion is not specific for 4RTs, but perfusion pattern expression may provide an additive value for the discrimination of 4RTs from other neurodegenerative diseases and correlates closer with clinical severity than tau pattern expression.