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Are novel oral oncolytics underdosed in obese patients?

Lishi LinEllen K O van der MeerNeeltje SteeghsJos H BeijnenAlwin D R Huitema
Published in: Cancer chemotherapy and pharmacology (2023)
Higher body weight was only correlated with lower plasma trough levels for crizotinib, imatinib, and trametinib. Therefore, patients with a high body weight may require dose escalation to obtain adequate target levels when treated with these oral oncolytics.
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