Rose bengal as photocatalyst: visible light-mediated Friedel-Crafts alkylation of indoles with nitroalkenes in water.

Zong-Yi YuJing-Nan ZhaoFan YangXiao-Fei TangYu-Feng WuCun-Fei MaBo SongLei YunQing-Wei Meng

Published in: RSC advances (2020)

A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium. Indoles reacted smoothly with nitroalkenes under the irradiation of visible-light and generated corresponding 3-(2-nitroalkyl)indoles in moderate to good yields (up to 87%).

Keyphrases

visible light
photodynamic therapy
randomized controlled trial
high intensity
radiation therapy
gold nanoparticles
electron transfer