Liver fat, bone marrow adipose tissue and bone mineral density in children with overweight.
Idoia Labayen GoñiCristina Cadenas-SánchezFernando IdoateMaría MedranoIgnacio TobalinaArantxa VillanuevaBeatriz Rodríguez-VigilNatalia Álvarez de EulateMaddi OsésRafael CabezaPublished in: The Journal of clinical endocrinology and metabolism (2023)
These findings suggest that hepatic steatosis, rather than overall excess adiposity, is associated with greater bone marrow adipose tissue in preadolescent children with overweight/obesity, which in turn, is related to a lower BMD. Hepatic steatosis could be a potential biomarker of osteoporosis risk, and a therapeutic target for interventions that aim to reduce not only hepatic steatosis, but for those designed to improve bone health in such children.
Keyphrases
- bone mineral density
- adipose tissue
- bone marrow
- insulin resistance
- postmenopausal women
- young adults
- weight loss
- weight gain
- body composition
- physical activity
- mesenchymal stem cells
- metabolic syndrome
- high fat diet
- type diabetes
- healthcare
- public health
- body mass index
- risk assessment
- skeletal muscle
- climate change
- sensitive detection
- fatty acid
- quantum dots