Probing conformational dynamics to understand kinase inhibition.

Published in: eLife (2023)

Why do some inhibitors select the on-state in ERK2, a kinase that is involved in many signaling pathways in cells, whereas others bind to more than one conformation?

Keyphrases

signaling pathway
induced apoptosis
molecular dynamics simulations
pi k akt
cell cycle arrest
single molecule
protein kinase
tyrosine kinase
endoplasmic reticulum stress
cell proliferation
molecular dynamics
epithelial mesenchymal transition
oxidative stress
cell death