Ian R Outhwaite

ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 22

Top Venues

The Journal of pharmacology and experimental therapeutics

Leukemia

Biochemical Society transactions

eLife

Memorial Sloan Kettering Cancer Center

Williams College (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Memorial Sloan Kettering Cancer Center

United States

Research Technician :: Stephen Long Lab, Sloan Kettering Institute

Education History

Williams College

United States

BSC

Publications

Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Ariel Leyte-Vidal, RosaAnna DeFilippis, Ian R Outhwaite, Isabelle Kwan, Ji Young Lee, Carlyn Leavitt, Kaeli B Miller, Delphine Rea, Aziz M Rangwala, Kevin Lou, Suhana Patel, Ailin Alvarez, Kevan M Shokat, Ivet Bahar, Markus A Seeliger, Neil P Shah
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia (2024)
Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Ariel Leyte-Vidal, RosaAnna DeFilippis, Ian R Outhwaite, Isabelle Kwan, Ji Young Lee, Carlyn Leavitt, Kaeli B Miller, Delphine Rea, Aziz M Rangwala, Kevin Lou, Suhana Patel, Ailin Alvarez, Kevan M Shokat, Ivet Bahar, Markus A Seeliger, Neil P Shah
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia 38 (9) (2024)
Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Ariel Leyte-Vidal, RosaAnna DeFilippis, Ian R Outhwaite, Isabelle Kwan, Ji Young Lee, Carlyn Leavitt, Kaeli B Miller, Delphine Rea, Aziz M Rangwala, Kevin Lou, Suhana Patel, Ailin Alvarez, Kevan M Shokat, Ivet Bahar, Markus A Seeliger, Neil P Shah
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia 38 (9) (2024)
Ariel Leyte-Vidal, RosaAnna DeFilippis, Ian R Outhwaite, Isabelle Kwan, Ji Young Lee, Carlyn Leavitt, Kaeli B Miller, Delphine Rea, Aziz M Rangwala, Kevin Lou, Suhana Patel, Ailin Alvarez, Kevan M Shokat, Ivet Bahar, Markus A Seeliger, Neil P Shah
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia 38 (9) (2024)
Ariel Leyte-Vidal, RosaAnna DeFilippis, Ian R Outhwaite, Isabelle Kwan, Ji Young Lee, Carlyn Leavitt, Kaeli B Miller, Delphine Rea, Aziz M Rangwala, Kevin Lou, Suhana Patel, Ailin Alvarez, Kevan M Shokat, Ivet Bahar, Markus A Seeliger, Neil P Shah
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia 38 (9) (2024)
Daniel P Radin, Sophie G Shifman, Ian R Outhwaite, Aryan Sharma, Robert Bases, Markus A Seeliger, Stella E Tsirka
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. The Journal of pharmacology and experimental therapeutics 389 (1) (2024)
Ian R Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, John D Chodera, Markus A Seeliger
Death by a Thousand Cuts â€" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology. bioRxiv : the preprint server for biology (2023)
Victoria R Mingione, YiTing Paung, Ian R Outhwaite, Markus A Seeliger
Allosteric regulation and inhibition of protein kinases. Biochemical Society transactions 51 (1) (2023)
Ian R Outhwaite, Markus A Seeliger
Probing conformational dynamics to understand kinase inhibition. eLife 12 (2023)
Ian R Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, John D Chodera, Markus A Seeliger
Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. eLife 12 (2023)
Victoria R Mingione, YiTing Paung, Ian R Outhwaite, Markus A Seeliger
Allosteric regulation and inhibition of protein kinases. Biochemical Society transactions 51 (1) (2023)
Victoria R Mingione, YiTing Paung, Ian R Outhwaite, Markus A Seeliger
Allosteric regulation and inhibition of protein kinases. Biochemical Society transactions (2023)
Victoria R Mingione, YiTing Paung, Ian R Outhwaite, Markus A Seeliger
Allosteric regulation and inhibition of protein kinases. Biochemical Society transactions 51 (1) (2023)
Alexander A Peterson, Aziz M Rangwala, Manish K Thakur, Patrick S Ward, Christie Hung, Ian R Outhwaite, Alix I Chan, Dmitry L Usanov, Vamsi K Mootha, Markus A Seeliger, David R Liu
Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nature chemical biology 18 (11) (2022)
Hannah E Phillips, Rebecca B Jennings, Ian R Outhwaite, Sarah Grosser, Mansi Chandra, Victoria J Ende, Stephen G Post
Motivation to Impact: Medical Student Volunteerism in the COVID 19 Pandemic. Medical science educator 32 (5) (2022)
Xiaowei Hou, Ian R Outhwaite, Leanne Pedi, Stephen Barstow Long
Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. eLife 9 (2020)

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Publication Activity (10 Years)

Top Topics

Top Venues

Ian R Outhwaite