Phase Ib Dose-escalation/Expansion Trial of Ribociclib in Combination With Everolimus and Exemestane in Postmenopausal Women with HR+, HER2- Advanced Breast Cancer.

Aditya BardiaShanu Modi Mafalda Oliveira Javier Cortes Mario CamponeBrigette MaLuc DirixAmy WeiseBecker HewesIvan Diaz-PadillaYu HanPriya DeshpandeTanay S SamantKaren Rodriguez LorencWei HeFei SuMariana Chavez-MacGregor

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Triplet therapy with endocrine therapy and mTOR and CDK4/6 inhibition provides clinical benefit and an acceptable safety profile in previously treated postmenopausal women with HR+, HER2- ABC.

Keyphrases

bone mineral density
clinical trial
study protocol
cell proliferation
cell cycle
randomized controlled trial
bone marrow
phase ii
energy transfer