Sjögren's and non-Sjögren's sicca share a similar symptom burden but with a distinct symptom-associated proteomic signature.

Valentina PucinoJason D TurnerSaba NayarFlorian KollertSaaeha RauzAndrea RichardsJon HighamAna Poveda-GallegoSimon J BowmanFrancesca BaroneBenjamin A Fisher

Published in: RMD open (2022)

Obesity-related metabolic factors may regulate symptoms in sicca. Further work should explore non-inflammatory drivers of high symptom burden in SjS to improve clinical trial outcomes.

Keyphrases

clinical trial
patient reported
metabolic syndrome
disease activity
insulin resistance
type diabetes
weight loss
oxidative stress
weight gain
open label
rheumatoid arthritis
systemic lupus erythematosus
study protocol
adipose tissue
skeletal muscle
randomized controlled trial
label free
drug induced