GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.
Hironosuke WatanabeHisashi SaharaShunichiro NomuraTatsu TanabeDilrukshi K Ekanayake-AlperLennan K BoydNathan J LourasArsenoi AsfourMakenzie A DantonSiu-Hong HoScott J ArnRobert J HawleyAkira ShimizuTakeshi NagayasuDavid AyaresMarc I LorberMegan SykesDavid H SachsKazuhiko YamadaPublished in: Xenotransplantation (2018)
To our knowledge, this is the first evidence of histologically viable porcine lung grafts beyond 7 days in baboons. Our results indicate that GalT-KO pig lungs are highly susceptible to acute humoral rejection and that this may be mitigated by transgenic expression of hCD47.