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Radical modulated regioselective difunctionalization of vinyl enynes: tunable access to naphthalen-1(2 H )-ones and allenic alcohols.

Xiao-Yu XieYun-Fang XuYang LiXiao-Dong WangJie ZhuLei Wu
Published in: Chemical communications (Cambridge, England) (2022)
A novel and efficient radical-modulated difunctionalization of vinyl enynes has been disclosed using TEMPO as a radical regulator. Facile access to structurally diverse 3-bromo-naphthalen-1(2 H )-ones and 4-bromo-allenic alcohols was realized via 1,2-addition/1,2-migration or 1,4-addition, respectively. This protocol represents the first example of radical-modulated metal-free difunctionalization of 1,3-enynes with high regioselectivity.
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