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Mucus clears from the trachea in a helix: a new twist to understanding airway diseases.

David AbelsonJames Di MichielClayton FraterMark PearsonRobert RussoMartin WechselbergerAlice M CotteeLucy Morgan
Published in: Thorax (2024)
For the first time, we show that human tracheal MCC is helical, and impairment in ex-smokers is often caused by flattened helical transit, not slower movement. Our methodology provides a simple method to map tracheal MCC and speed in vivo.
Keyphrases
  • endothelial cells
  • epithelial mesenchymal transition
  • smoking cessation
  • induced pluripotent stem cells
  • pluripotent stem cells
  • dna binding