PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway.

Anjian XuYanmeng LiWenshan ZhaoFei HouXiaojin LiLan SunWei ChenAiting YangShanna WuBei ZhangJingyi YaoHuan WangJian Huang

Published in: Journal of molecular medicine (Berlin, Germany) (2017)

PHP14 is up-regulated in fibrotic liver and activated hepatic stellate cells. The expression of PHP14 is induced by TGF-β1. The migration of hepatic stellate cells is regulated by PHP14. PHP14 is a mediator of TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway in hepatic stellate cells.

Keyphrases

cell cycle arrest
pi k akt
induced apoptosis
signaling pathway
cell death
cell proliferation
liver fibrosis
transforming growth factor
endoplasmic reticulum stress
poor prognosis
epithelial mesenchymal transition
systemic sclerosis
transcription factor