Evaluating the effectiveness of RNA in-situ hybridization for detecting lung adenocarcinoma with anaplastic lymphoma kinase rearrangement.
Naoki NakajimaAkihiko YoshizawaKyoko KondoMariyo Rokutan-KurataMasahiro HirataAyako FuruhataShinji SumiyoshiMakoto SonobeToshi MenjuMasanobu MomoseMasakazu FujimotoHiroshi DateHironori HagaPublished in: Histopathology (2017)
Our findings show that RNA ISH is useful for detecting ALK rearrangement with high sensitivity and specificity relative to conventional IHC/FISH tests. Thus, RNA ISH, which is an easy and rapid assay, could be an alternative method to IHC and FISH.