Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer.
Anna Chiara WünschElena RiesSina HeinzelmannAndrea FrabschkaPeter Christoph WagnerTheresa RauchCorinna KodererMohamed El-MeseryJulian Manuel VollandAlexander Christian KüblerStefan HartmannAxel SeherPublished in: Current issues in molecular biology (2023)
In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine restriction (MetR) in selected HNSCC cell lines. We investigated the influence of MetR on cell proliferation and vitality, the compensation for MetR by homocysteine, the gene regulation of different amino acid transporters, and the influence of cisplatin on cell proliferation in different HNSCC cell lines.
Keyphrases
- amino acid
- poor prognosis
- cell proliferation
- cardiovascular disease
- cancer therapy
- long non coding rna
- type diabetes
- induced apoptosis
- cell cycle
- cell cycle arrest
- human health
- signaling pathway
- pi k akt
- metabolic syndrome
- risk assessment
- cell death
- cardiovascular risk factors
- atomic force microscopy
- climate change
- insulin resistance
- binding protein
- high resolution