Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial.
Daniel A JonesAnne-Marie BeirneMatthew KelhamLucinda WynneMervyn AndiapenKrishnaraj S RathodTipparat ParakawJessica AdamsAnnastazia LearoydKamran KhanThomas GodecPaul WrightSotiris AntoniouAndrew WraggMuhammad YaqoobAnthony MathurAmrita AhluwaliaPublished in: European heart journal (2024)
In patients at risk of renal injury undergoing coronary angiography for ACS, a short (5 day) course of once-daily inorganic nitrate reduced CIN, improved kidney outcomes at 3 months, and MACE events at 1 year compared to placebo.
Keyphrases
- acute coronary syndrome
- nitric oxide
- drinking water
- phase iii
- percutaneous coronary intervention
- high glucose
- magnetic resonance
- clinical trial
- antiplatelet therapy
- study protocol
- water soluble
- phase ii
- randomized controlled trial
- coronary artery disease
- open label
- endothelial cells
- perovskite solar cells
- double blind
- adipose tissue
- skeletal muscle
- glycemic control