Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents.
Asami TsukiashiKil Sik MinHikaru KitayamaHiroaki TerasawaSosuke YoshinagaMitsuhiro TakedaLeonard F LindoyShinya HayamiPublished in: Scientific reports (2018)
Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.
Keyphrases
- water soluble
- contrast enhanced
- room temperature
- oxide nanoparticles
- magnetic resonance imaging
- magnetic resonance
- single molecule
- diffusion weighted imaging
- open label
- density functional theory
- computed tomography
- double blind
- placebo controlled
- drug delivery
- cancer therapy
- randomized controlled trial
- clinical trial
- ionic liquid
- molecular dynamics
- transition metal
- study protocol
- aqueous solution
- light emitting