Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies.
James J HardingSubhiksha NandakumarJoshua ArmeniaDanny N KhalilMelanie AlbanoMichele LyJinru ShiaJaclyn F HechtmanRitika KundraImane El DikaRichard Kinh Gian DoYichao SunT Peter KinghamMichael I D'AngelicaMichael F BergerDavid M HymanWilliam JarnaginDavid S KlimstraYelena Y JanjigianDavid B SolitNikolaus SchultzGhassan K Abou-AlfaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Linking NGS to routine clinical care has the potential to identify those patients with HCC likely to benefit from standard systemic therapies and can be used in an investigational context to match patients to genome-directed targeted therapies.See related commentary by Pinyol et al., p. 2021.