Natural history of circulating miRNAs in Duchenne disease: Association with muscle injury and metabolic parameters.
Tomas Almeida-BecerrilMaricela Rodríguez-CruzSthephanie Yannín Hernández-CruzEugenia Dolores Ruiz-CruzChristian Ricardo Sánchez MendozaAlan Cárdenas-ConejoRosa Elena Escobar-CedilloFederico Ávila-MorenoGuillermo Aquino-JarquinPublished in: Acta neurologica Scandinavica (2022)
Non-ambulatory DMD patients have lower circulating dystromiRs and OS-R miRNAs levels than ambulatory DMD patients. The progressive muscle injury is associated with a decrease in the expression of those miRNAs, evidencing DMD progress. These findings add new information about the natural history of DMD.